Abstract
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alpha(IIb)beta(3) on washed human platelets.
MeSH terms
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Binding, Competitive / drug effects
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Biological Assay
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Drug Evaluation, Preclinical
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Humans
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Molecular Mimicry
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Molecular Structure
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Phthalic Acids / chemical synthesis
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Phthalic Acids / chemistry
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Phthalic Acids / pharmacology*
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / chemical synthesis
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology*
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Platelet Glycoprotein GPIIb-IIIa Complex / drug effects
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Protein Binding / drug effects
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Receptors, Fibrinogen / antagonists & inhibitors*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Phthalic Acids
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Platelet Aggregation Inhibitors
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Platelet Glycoprotein GPIIb-IIIa Complex
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Receptors, Fibrinogen
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isophthalate